Born in Puerto Rico, Regina attended Sarah Lawrence College and New York University's Department of Design for Stage and Film where she received her MFA in Scenic Design. Recently completed projects include: The Homosexuals by Philip Dawkins, directed by Bonnie Metzgar at About Face Theatre; Ruined by Lynn Nottage, directed by Ron Himes at the St. Louis Black Rep; and 26 Miles by Quiara Alegria Hudes, directed by Tara Mallen for Rivendell and Teatro Vista. She has designed for directors Giovanna Sardelli, Daniella Topol, Thomas Kail, Victor Maog, Jorge Ali Triana, Michael J. Garces, and Bartlett Sher, amongst others; and for renowned Latino theaters including Repertorio Español, the Puerto Rican Traveling Theater, INTAR, and was the Resident Scenic Designer at Pregones Theater, Bronx, for more than ten years.

Regina has received a 2011 Princess Grace Foundation USA Special Project grant to serve as production designer for the upcoming workshop of Stephen Taylor's Paradises Lost at the Krannert Center for the Performing Arts. She is also a Fellow of the NEA/TCG Career Development Program for Designers; and a recipient of both a Princess Grace Award, for her work with Pregones, and a Latino ACE Award.

She is part of the Scenic Design Faculty at the University of Illinois, Urbana-Champaign, and a member of United Scenic Artists Local 829 and USITT.