Born in Santurce, Puerto Rico, Regina attended Sarah Lawrence College and New York University's Department of Design for Stage and Film where she received her MFA in Scenic Design. Recently completed projects include: Astral Convertible 2010 with original choreography by Trisha Brown and re-imagined technology by John Toenjes at the Krannert Center for the Performing Arts; Sarafina!, My Secret Language of Wishes and Blues in the Night , directed by Ron Himes at The St. Louis Black Repertory. She has also designed for directors Giovanna Sardelli, Daniella Topol, Thomas Kail, Victor Maog, Jorge Ali Triana, Michael J. Garces, Miriam Colon and Bartlett Sher, amongst others. She has also worked with renowned Latino theaters including Repertorio Español, Puerto Rican Traveling Theater, INTAR, and was the Resident Scenic Designer at Pregones Theater for more than eight years.

She is part of the Scene Design Faculty at University of Illinois, Urbana-Champaign, and a member of USA 829 and USITT. Regina was also selected to participate in the 2004-06 NEA/TCG Career Development Program for Designers, during which she participated in the 7th Annual LaMaMa Symposium for Directors in Spoleto, Italy. Regina is also a recipient of a 2002 Princess Grace Award in Scenic Design for her work with Pregones and a Latino ACE Award for her designs for Borinquen vive en el barrio.

She studied with artists Andy Bueso, Jaime Suarez, and designers John Conklin, Paul Steinberg, Lowell Detweiller, Eduardo Sicangco, Susan Hilferty and Campbell Baird.